I know what you mean.. there are a LOT of times when I feel lonely, too. And being a part of this site does help, but I believe what we're looking for are deeper connections in our everyday lives. I'm really blessed to have a family that is very understanding, but there are still times when I wish people would understand me on the deep level that I seem to understand them (including my family)
I think, as you also mentioned, that making a difference in the world is at the heart of fulfillment for people like us. I feel this constant desire to be helping people. For me, it lessens the everyday loneliness because I can better see the beneficial aspects of these gifts. I hope something comes along for you, and that you keep looking for ways to make a difference, because I know there are lots of ways, especially if we get creative. Also, if you're like me, change is hard to adapt to, even if it's positive and necessary, but I guess the best way to look at it is that change makes room for new opportunities and better experiences.
Anyway, I hope this helps at least a little bit and that things get less overwhelming soon..